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If pharmaceuticals occur in the environment, they can cause potential problems due to possible accumulation in the environment. Biodegradation transforms xenobiotics into less complex and non-toxic compounds using microorganisms rather than chemicals that create their own disposal problems. Biodegradation can make use of genetically modified microorganisms, which raises ethical and ecological issues, or it can make use of microorganisms that occur in the environment. The aim of this work was to study biodegradation of pharmaceutical erythromycin by environmental microorganisms. Initial concentration of erythromycin and Pseudomonas aeruginosa 3011 ranged from 2 μg dm-3 to 200 mg dm-3 and 6.25±0.35 mg dm-3. Half maximal inhibitory concentration was 124.2 mg dm-3. The results from antimicrobial susceptibility experiment showed that P. aeruginosa 3011 is resistant to erythromycin. Average biodegradation efficiency was 33.43 %. These results suggest that pharmaceuticals in waste can be efficiently biodegraded through selection of appropriate naturally occurring microorganisms and optimization of degradation conditions.

Biodegradation of Erythromycin with Environmental Microorganism Pseudomonas aeruginosa 3011