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Induction of Hsp can trigger by cellular stressors caused by viral infections. The aim of this study is to find out of the expression of Hsp70 on C.altivelis exposured by infection of VNN. The methods were to isolate fractionate the protein of C.altivelis organs both normal and infected by of VNN by SDS-Page, and to detect the expression of Hsp70 qualitatively on tissue using Immunohistochemistry (IHC) methods. The result shows the IHC test was a positive Hsp70. The infection of VNN that have immunogenic protein on tissue organ of C.altivelis had been reacted by expression of function Hsp70. It means antigen determinant from the immunogenic protein of VNN has sensitivity highly on the reaction of Hsp70. Hsp70 can induce immune cell for the maintenance of Humpback grouper tissue receptors. The conclusion was the infection of VNN of C.altivelis was related to the expression of Hsp70. the weakening of the immune response in these organs (4). VNN attack causes a necrosis beginning from the inclusion body i.e. the cells undergo changes in the cytoplasm with the formation black dots. The subsequent event is the cells undergo a cell enlargement until the formation of a vacuole in the cell cytoplasm. It is a response to antigen attacks that occurring in the cell. The cellular response against an antigen can cause tissue damage. This damage begins with an inflammatory process as a result of a reaction of the host immune cells in the body (5). VNN (RNA viral) infection triggers the activated inflammatory cells in the body. Similarly, tissue damage suffered an injury cell as a result of an inflammatory reaction in the body. The next response of inflammatory reaction released the immune cells to make mediators or cell-mediated immunity on further immune reaction (6-7).

Heat Shock Protein (Hsp) Response Within RNA Viral Nervous Necrosis (VNN) that Infect of the Humpback grouper Cromileptes altivelis