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As part of our ongoing efforts in the development of new  18 F-labeled peptides for clinical PET imaging, a new two-step  18 F-labeling methodology based on the chemoselective oxime formation between an unprotected aminooxy-functionalized peptide and a  18 F-labeled aldehyde was investigated and optimized.

Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation