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The aim of this study is to radiolabel ganciclovir, known as having selective antiviral properties against thymidine kinase, with technetium tricarbonylcore ( 99m Tc(CO) 3  + ) and to investigate the biological behavior of this complex  in vitro  and  in vivo . Commercially provided Ganciclovir (GCV) was radiolabeled with  99m Tc(CO) 3  + . Initially, optimum radiolabeling conditions were determined by analyzing factors such as temperature, pH and time. Quality control of the radiolabeled compound was performed. The radiolabeling yield was found to be 97%. The  99m Tc(CO) 3 -GCV complex also displayed good  in vitro  stability during the 24 h period.  In vitro  cell uptake studies showed that the  99m Tc(CO) 3 -GCV complex is highly uptaken in A-549, PC-3, HeLa cell lines according to the control group  99m Tc(I)-tricarbonyl core. The knowledge gained from  in vivo  and  in vitro  studies of  99m Tc(CO) 3 -GCV could contribute to the development of a new HSV1-tk gene imaging agent.

Thymidine kinase enzyme selective imaging radiopharmaceutical: 99m Tc(CO) 3 -Ganciclovir