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Fast progressing  immuno -PET gives reasons to develop new potential medium-long and long-lived radioisotopes. One of the promising candidates is  90 Nb. It has a half-life of 14.6 h, which allows visualizing and quantifying processes with medium and slow kinetics, such as tumor accumulation of antibodies and antibodies fragments or polymers and other nanoparticles.  90 Nb exhibits a high positron branching of 53% and an optimal energy of  β  +  emission of  E  mean =0.35 MeV   only. Consequently, efficient radionuclide production routes and Nb V  labeling techniques are required.

90 Nb – a potential PET nuclide: production and labeling of monoclonal antibodies