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Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs or tissues with an aim of minimizing unwanted radiation to surrounding healthy tissue. In this work, [ tris (1,10-phenanthroline) [ 153 Sm]samarium(III)]trithiocyanate ( 153 Sm-TPTTC) was developed for possible therapeutic properties. The cold compound,  i.e.  nat Sm-TPTTC was prepared and characterized by IR, UV, mass and  1 H-NMR spectroscopy.  153 Sm-TPTTC was prepared in two steps using [ 153 Sm]SmCl 3 , obtained by neutron activation of an enriched  152 Sm sample. Stability tests, partition coefficient determination, toxicity tests and biodistribution studies of the complex in wild-type and fibrosarcoma-bearing mice were determined. The radiolabeled complex was prepared in high radiochemical purity (&gt; 99% precipitation method) and specific activity of 278 GBq/mmol and demonstrated significant stability at 4, 25 and 37 ºC (in presence of human serum). Initial complex biodistribution data showed significant liver accumulation in wild-type mice and significant tumor accumulation in fibrosarcoma-bearing mice with tumor:blood and tumor:muscle ratios of 3.55 (2 h) and 38.26 (96 h) respectively.  153 Sm-TPTTC properties suggest an efficient tumor targeting agent with high tumor-avidity. Further investigation on the therapeutic properties must be conducted.

radiochimica acta

Synthesis, quality control and biological evaluation of  tris [(1,10-phenanthroline)[ 153 Sm]samarium(III)]trithiocyanate complex as a therapeutic agent