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Proton irradiation of natural and enriched SrCl 2  targets was used to produce PET radioisotope  86 Y. The proton energy was degraded from the incident 117.8 MeV to induce the  88 Sr( p ,3 n ) reaction. For the irradiation three pellets made of  nat SrCl 2  (6.61 and 74.49 g) and  88 SrCl 2  (5.02 g) were pressed and individually encapsulated in stainless steel target bodies. The two smaller targets were irradiated for 0.5–1 h at the energy ∼ 46→37 MeV to take advantage of the peak in the excitation function of the  88 Sr( p ,3 n ) reaction. The larger target was irradiated at 66.4→44.6 MeV. The irradiated pellets were chemically processed to selectively separate  86 Y radioisotope using Eichrom DGA ( N , N , N´ , N´ -tetra- n -octyldiglycolamide) resin. The production yields of  86 Y were determined to be 10–13 mCi/μA h. Coproduction of  87m Y in the final product was 34% for  nat SrCl 2  and 54% for  88 SrCl 2  target. The chemical separation yield of yttrium reached 88–92%. The developed chemical procedure allows for the same day processing and shipment of the isotope to users.

Irradiation of strontium chloride targets at proton energies above 35 MeV to produce PET radioisotope Y-86