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The radionuclide-generator based access to radiopharmaceutical isotopes represents a valuable alternative to directly produced isotopes at particle accelerators or nuclear reactors. The   44 Ti based generator is of increasing interest for the delivery of PET-radiopharmaceutical isotopes used for imaging. The product of this generator   44 Sc represents with its 3.97 h half-life and 94.3% positron branching [1] a very promising candidate for labeling PET radiopharmaceuticals. The long half-life of 58.9±0.3 y [2] of the   44 Ti assures a constant and long lasting production of the daughter nuclide.

The thermal release of scandium from titanium metal – a simple way to produce pure 44 Sc for PET application