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Since, to date very limited information on the distribution and function of the adenosine A 3  receptor is available, the development of suitable radioligands is needed. Recently, we introduced [  18 F]FE@SUPPY (5-(2-[  18 F]fluoroethyl) 2,4-diethyl-3-(ethylsulfanylcarbonyl)-6-phenylpyridine-5-carboxylate) as the first PET-ligand for the A3R. Regarding the metabolic profile – this class of dialkylpyridines comprises two ester functions within one molecule, one carboxylic and one thiocarboxylic – one could expect carboxylesterases significantly contributing to cleavage and degradation. Therefore, our aim was the development of [  18 F]FE@SUPPY:2 (5-ethyl 2,4-diethyl-3-((2-[  18 F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate), the functional isomer containing the label at the thiocarboxylic moiety.

radiochimica acta

Radiosynthesis of a novel potential adenosine A 3  receptor ligand, 5-ethyl 2,4-diethyl-3-((2-[ 18 F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate ([ 18 F]FE@SUPPY:2)