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Rhenium-188 is a well recognized therapeutic radionuclide and its use in a variety of applications has been reported. The current methods of obtaining “no-carrier added”   188 Re from conventional alumina based generators require   188 W of very high specific activity for obtaining reasonable quantities of   188 Re in an adequately concentrated form. We have developed a simple electrochemical separation technique adaptable for using low specific activity   188 W, for the separation of   188 Re from   188 W, and obtain   188 Re amenable for radiolabeling biomolecules. The overall decay corrected yield of   188 Re was &gt;70%. The recovered   188 Re had high radiochemical (&gt;97%) and radionuclidic purity (&gt;99.99%). The suitability of the   188 Re for radiolabeling was demonstrated by its use for the complexation of DMSA and HEDP with labeling yields &gt;98%. Repeated separation of   188 Re from a stock solution of   188 W could be demonstrated for a period of 70 d. The preliminary results suggest that the process can be scaled up to higher activity levels and suggest that this strategy can be further explored for the development of electrolytic type   188 W/  188 Re generator suitable for clinical applications.

A novel 188 W/ 188 Re electrochemical generator with potential for medical applications