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Ceragenins (CSAs) are a new class of antimicrobial agents that display broad spectrum antibacterial activity and may find use in the treatment of various infections. A member of this class CSA-13 was labelled with  99m Tc using SnCl 2 ·H 2 O as a reducing agent. The labelling efficiency depended on the ligand/reductant ratio, pH and volume of the reaction mixture. The radiochemical purity and stability of  99m Tc-CSA was determined by thin layer chromatography. Biodistribution studies of  99m Tc-CSA were performed in Sprague Dawley rats. Liver and spleen uptake was quite high. A significantly higher accumulation of  99m Tc-CSA was seen at sites of   S. aureus   infected rats. The results were compared with  99m Tc-Ciprofloxacin.

Preparation, quality control and biological evaluation of 99m Tc-labelled cationic steroid antibiotic (CSA-13)