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140 Nd was produced by irradiations of CeO 2  and Pr 2 O 3  targets leading to  nat Ce( 3 He, xn )  140 Nd and  141 Pr( p ,2 n )  140 Nd nuclear reactions. The practical yield of  140 Nd at EOB in the former reaction over the energy range of  E   3 He  = 33.5 → 0 MeV amounted to 3.5 MBq/μA h and in the latter reaction over the energy range of  E  p  = 18.6→16.2 MeV to 15.5 MBq/μA h. These values correspond to about 41% and 60% of the respective theoretical values. Successful separations of the radionuclide were performed by means of cation-exchange chromatography resulting in decontamination factors of ≥10 8  and ≥7×10 5  for the cerium and praseodymium target materials, respectively. With the no-carrier-added  140 Nd obtained, an efficient  140 Nd/ 140 Pr radionuclide generator system was developed and evaluated. The principle of the radiochemical separation is based on physico-chemical transitions (hot-atom effects) of the daughter  140 Pr following the electron decay process of  140 Nd. The parent radionuclide  140 Nd(III) is quantitatively adsorbed on a solid phase matrix in the form of  140 Nd-DOTA-conjugated complexes. The daughter nuclide  140 Pr is generated in an ionic species and is easily separated using low volumes of various aqueous eluents. The elution yield is at least 93%, if an optimized eluent, such as DTPA solution is applied. The system remains stable at least over three half-lives of  140 Nd, with high radiolytic stability and low  140 Nd breakthrough. This radionuclide generator system  140 Nd ( T  1/2  = 3.37 d) provides the short-lived positron-emitting radiolanthanide  140 Pr ( T  1/2  = 3.4 min) for molecular imaging using positron emission tomography (PET).

A 140 Nd/ 140 Pr radionuclide generator based on physico-chemical transitions in 140 Pr complexes after electron capture decay of 140 Nd-DOTA