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Due to interesting tumor seeking properties of  bis -thiosemicarbazones, two radio palladium-  bis  -thiosemicarbazone complexes,  i.e. , [ 103 Pd]-pyruvaldehyde-  bis ( N  4 -methylthiosemicarbazone) ([ 103 Pd] PTSM) and [ 103 Pd]-  di -acetyl- bis  ( N  4 -methylthiosemicarbazone) ([ 103 Pd]ATSM) were prepared according to the analogy of radio copper homologs. Palladium-103 ( t  1/2 =16.96 d) was produced  via  the  103 Rh( p , n )  103 Pd nuclear reaction with proton energy 18 MeV. The final activity was eluted in form of Pd(NH 3 ) 2 Cl 2  in order to react with  bis  -thiosemicarbazones to yield [ 103 Pd]-labeled compounds. Chemical purity of the product was confirmed to be below the accepted limits by polarography. [ 103 Pd]-labeled  bis  -thiosemicarbazones were prepared with a radiochemical yield of more than 80% at room temperature after 60–90 min by vortexing a mixture of thiosemicarbazones and Pd activity in ethanol. The purification of the labeled compounds performed by reverse phase column chromatography using C 18  plus Sep-Pak. Radiochemical purity of more than 99% specific activity of about 12500–13000 Ci/mol was obtained. The stability of the complexes was checked in final product and presence of human serum at 37 °C up to 48 h. The partition co-efficients of the final complexes were determined. The initial physico-chemical properties of the labeled compounds were compared to those of their copper homologues.

Development of [ 103 Pd]-labeled- bis ( N 4 -methylthiosemicarbazone) complexes as possible therapeutic agents