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Vancomycin Hydrochloride is an antibiotic produced by the growth of certain strains of Streptomyces orientalis. As Vancomycin Hydrochloride is poorly absorbed after oral administration; it is given intravenously for therapy of systemic infections. Vancomycin was labeled with technetium-99m pertechnetate using SnCl 2 ·2H 2 O as reducing agent. The labeling efficiency depends on ligand/reductant ratio, pH, and volume of reaction mixture. Radiochemical purity and stability of  99m Tc-Vancomycin was determined by thin layer chromatography. Biodistribution studies of  99m Tc-Vancomycin were performed in a model of bacterial infection in Sprague–Dawley rats. A significantly higher accumulation of  99m Tc-Vancomycin was seen at sites of S. aureus infected animals. Whereas uptake of  99m Tc-Vancomycin in turpentine inflamed rats were quite low.

Synthesis and biodistribution of 99m Tc-Vancomycin in a model of bacterial infection