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Some features of a novel  90 Sr- 90 Y generator which employs supported liquid membrane (SLM) to separate carrier-free  90 Y from  90 Sr present in the high level waste of the spent fuel of reactor are described. After ascertaining the purity of  90 Y particularly with respect to  90 Sr breakthrough, its complexation was studied with a few oxo/aza donor ligands, such as DTPA, EDTMP, DOTA, TETA and a cyclic phosphonate, CTMP. These studies were primarily carried out to adjudge the quality of the  90 Y obtained from a novel  90 Sr- 90 Y generator and ascertain its usability for labelling biomolecules such as antibodies and peptides. The DOTA complexes are most stable at 37  C in human serum; they appear to be ideal bifunctional chelating agent for use in radioimmunotherapy with  90 Y.

Complexation studies with 90 Y from a novel 90 Sr- 90 Y generator