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A method is described for the production of  223 Ra ( t  1/2 =11.4 d) in a quality useful for endoradiotherapeutic applications.  The method is based on a long term operating generator with a source of  227 Ac ( t  1/2 =21.7 years), from which  223 Ra is eluted. The  227 Ac was isolated from a  231 Pa source using the f-element selective extraction chromatographic material TRU-resin. The purified  227 Ac/ 227 Th source was  subsequently applied to another extraction chromatographic resin, containing the extractant P,P ′ -di(2-ethylhexyl)methanediphosphonic acid on silica (Dipex-2) and used as a generator for  223 Ra. From the generator column, the yield of  223 Ra was about 60 kBq per 100 kBq of  227 Ac with a highly effective separation of  223 Ra from the precursors. In production runs, the activity of  227 Ac was found to be 6×10 -6  relative to the eluted activity of  223 Ra. By using a second column of Dipex-2 for additional purification, the activity of Ac was reduced to below 7×10 -8  relative  to  223 Ra with nearly quantitative recovery of  223 Ra. The described procedure resulted in a high purity  223 Ra preparation, potentially useful in,  e.g ., targeted radiotherapy of tumors.

223 Ra for endoradiotherapeutic applications prepared from an immobilized 227 Ac/ 227 Th source