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Resveratrol is a natural polyphenol. It protects skin from skin injury, ultraviolet radiation and pathogenic attack. This study is to find the optimum condition for the preparation of ethosome loading amount of resveratrol in ethosome. Ethosomes were prepared by modified hydrated liquid crystal method. Investigation of factors affecting the entrapment efficiency and particle size of ethosomes was carried out. The particle size of ethosome were measured by particle analyzer. The loading efficiency of resveratrol in ethosome was measured by HPLC. The particle sizes were 111.2 ~ 112.8 nm and the loading efficiency of resveratrol was 81.25 ~ 88.75%. The optimum conditions for the preparation of ethosome was obtained from of lecithin : resveratrol : cholesterol : ethanol at a weight ratio of 2.0 : 0.08 : 0.05 : 20.0.

A Study for Preparation of Nano Ethosome Loaded with Resveratrol