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, ,       .       ,       ,            , , ,      .   (natural moisturizing factor, NMF)        ,       .       , ,   (Cell Bio Fluid SyncTM)     ,           .       HaCaT  ,     3  PBS       DMEM   PBS,  (Cell Bio Fluid $Sync^{TM}$ )  3 .  MTT assay   .        21  .     1  , , ,     .      ( $22{\pm}2^{\circ}C$ , $50{\pm}5%$ ) 20   .   SPSS ver. 21  .  ,  (Cell Bio Fluid $Sync^{TM}$ )      , , , ,        . 【Body fluid has been studied for diverse fields like Ringer's solutions, artificial joint fluids, cell growth culture media because it plays a crucial role in controlling body temperature and acts as a solvent for diverse metabolite processes in the body and delivery media of mineral, energy source, hormone, signal and drug from and to cell via blood or lymphatic vessel by osmotic pressure or active uptake. Stratum corneum containing extracellular lipids and NMF (natural moisturizing factor) absorbs atmospheric water residing outside of cells and utilize it to hydrate inside of their own. This process is related to skin barrier function. In this study, we conducted the cell viability test with Cell Bio Fluid $Sync^{TM}$ , which mimicks body fluids including amino acids, peptides, and monosaccharides to strengthen skin barrier, and the clinical skin improvement test with cosmetics containing Cell Bio Fluid $Sync^{TM}$ . In the cell viability test, HaCaT cell was treated with PBS for 3 hours, followed by the treatment of a cell culture medium (DMEM) and isotonic solution (PBS) and Cell Bio Fluid $Sync^{TM}$ for 3 hours each. Then, MTT assay and image analysis were conducted. In the clinical skin improvement test, twenty-one healthy women participated. Participants applied cosmetics containing Cell Bio Fluid $Sync^{TM}$ on their face for a week and evaluated the skin hydration, skin roughness, brightness and evenness. All measurements were conducted after they washed off their face and took a rest under the constant temperature ( $22{\pm}2^{\circ}C$ ) and constant humidity conditions ( $50{\pm}5%$ ) for 20 minutes. All the data were analyzed by SPSS (version 21) software program. Results showed that Cell Bio Fluid $Sync^{TM}$ improved both the cell viability and in vivo skin conditions such as skin hydration, roughness, brightness and evenness.】

Effect of Cosmetics Contained Isotonic Water Mimicked Body Fluid on Cell Activities and Skin