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Hyperpolarization-activated cyclic nucleo-tide-gated (HCN) channels are permeable to Na+/K+ and underlie the inwardly rectifying current termed I h, I (f), or I q ([Santoro and Tibbs, 1999][1]). Regulated by voltage and the binding of ligands, there are four HCN isoforms that vary in their

the journal of neuroscience/the journal of neuroscience

p38 Mitogen-Activated Protein Kinase: A Novel Modulator of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and Neuronal Excitability: Figure 1.