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The transcription of the immediate-early genes Arcand Homer 1a (H1a) is dynamically regulated in response to synaptic activity; their protein products function at the postsynaptic sites of excitatory synapses. Previous studies demonstrate a role for Arc in the maintenance of long-term potentiation and in memory consolidation processes and indicate a role for H1a in modifying glutamatergic signaling pathways. Using double-label fluorescence in situ hybridization, we demonstrate that Arc andH1a RNA expression is induced strongly in the same neurons of rat hippocampus and neocortex after exploration of a novel environment. These findings support the view that novel experience activates a cell-specific genomic program and that Arcand H1a may function in concert in the structural and functional modifications of dendrites that lead to long-term changes in synaptic efficacy.

the journal of neuroscience/the journal of neuroscience

Experience-Dependent Coincident Expression of the Effector Immediate-Early Genes<i>Arc</i>and<i>Homer 1a</i>in Hippocampal and Neocortical Neuronal Networks

Experience-Dependent Coincident Expression of the Effector Immediate-Early GenesArcandHomer 1ain Hippocampal and Neocortical Neuronal Networks