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The collagen-tailed forms of acetylcholinesterase (AChE) are accumulated at mammalian neuromuscular junctions. The A4, A8, and A12 forms are expressed differently in the rat fast and slow muscles; the sternomastoid muscle contains essentially the A12 form at end plates, whereas the soleus muscle also contains extrajunctional A4 and A8 forms. We show that collagen Q (ColQ) transcripts become exclusively junctional in the adult sternomastoid but remain uniformly expressed in the soleus. By coinjectingXenopus oocytes with AChET and ColQ mRNAs, we reproduced the muscle patterns of collagen-tailed forms. The soleus contains transcripts ColQ1 and ColQ1a, whereas the sternomastoid only contains ColQ1a. Collagen-tailed AChE represents the first evidence that synaptic components involved in cholinergic transmission may be differently regulated in fast and slow muscles.

the journal of neuroscience/the journal of neuroscience

Differences in Expression of Acetylcholinesterase and Collagen Q Control the Distribution and Oligomerization of the Collagen-Tailed Forms in Fast and Slow Muscles