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Synaptic plasticity at excitatory glutamatergic synapses is believed to be instrumental in the maturation of neuronal networks. Using whole-cell patch-clamp recordings, we have studied the mechanisms of induction and expression of long-term depression at excitatory GABAergic synapses in the neonatal rat hippocampus (LTDGABA-A). We report that the induction of LTDGABA-A requires a GABAA receptor-mediated membrane depolarization, which is necessary to remove the Mg2+ block from postsynaptic NMDA receptors. LTDGABA-A is associated with an increase in the coefficient of variation of evoked GABAA receptor-mediated synaptic currents and a decrease in the frequency, but not amplitude, of Sr2+-induced asynchronous GABAA quantal events. We conclude that LTDGABA-A induction requires the activation of both GABAA and NMDA postsynaptic receptors and that its expression is likely presynaptic.

Mechanisms of Induction and Expression of Long-Term Depression at GABAergic Synapses in the Neonatal Rat Hippocampus