English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Somatostatin is known to mediate its actions through five G-protein-coupled receptors (sst1–sst5). We have studied the expression of the sst1 receptor in the rat hypothalamus by using a subtype-specific antiserum. In Western blotting, the antiserum reacted specifically with a band with an apparent molecular weight of 80,000 in membranes prepared from hypothalamic tissue. The localization of the sst1 receptor was investigated by immunohistochemistry in hypothalamus sections. Additionally, an immunofluorescent double-labeling was performed for the sst1 receptor and somatostatin. Light microscopy revealed that the sst1 receptor is located in perikarya and nerve fibers in the rostral periventricular area surrounding the third ventricle as well as in nerve fibers projecting from the perikarya to the external layer of the median eminence. In these neuronal structures, sst1 immunoreactivity was found to be colocalized with somatostatin. Furthermore, the location of sst1 receptors was studied by immunoelectron microscopy in the median eminence. In the external layer, receptor immunoreactivity was confined to nerve terminals. Immunoreactive nerve terminals were seen to make synapse-like junctions with other both stained and unstained nerve terminals. Thus, the sst1 receptor is present in the classic somatostatinergic hypothalamic parvocellular system inhibiting hormone secretion from the anterior pituitary gland. These findings indicate that the sst1 receptor may act as an autoreceptor and inhibit the release of somatostatin from periventricular neurons projecting to the median eminence.

the journal of neuroscience/the journal of neuroscience

Immunohistochemical and Cytochemical Localization of the Somatostatin Receptor Subtype sst<sub>1</sub>in the Somatostatinergic Parvocellular Neuronal System of the Rat Hypothalamus

Immunohistochemical and Cytochemical Localization of the Somatostatin Receptor Subtype sst1in the Somatostatinergic Parvocellular Neuronal System of the Rat Hypothalamus

Immunohistochemical and Cytochemical Localization of the Somatostatin Receptor Subtype sst₁in the Somatostatinergic Parvocellular Neuronal System of the Rat Hypothalamus