English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Nociceptin (orphanin FQ) is a novel, opioid-like, heptadecapeptide that is an endogenous ligand for the opioid receptor-like (ORL1) receptor. Unlike classical opioids, nociceptin can produce hyperalgesia when injected intracerebroventricularly into mice. Despite this, nociceptin has been reported to decrease transmitter release, activate an inwardly rectifying K+ conductance, and suppress high-voltage-activated Ca2+ channel conductances (HVA gCa) in much the same way as μ-, δ-, and κ-opioids. We report an action of nociceptin that is not shared by morphine: the suppression of low-voltage-activated, transient calcium (barium) current (IBa,T) in acutely dissociated rat dorsal root ganglion (DRG) neurons (EC50 = 100 nm). This effect was reflected as inhibition of bursts of action potentials that can be evoked in “medium-sized” DRG neurons. Experiments with GTP-γ-S (100 μm), GDP-β-S (2 mm), or aluminum fluoride (AlF3) (100 μm) in the patch pipette failed to provide evidence for G-protein involvement in nociceptin-inducedIBa,T suppression. By contrast, both morphine and nociceptin suppressed HVAgCa, and the latter response was affected by intracellular GTP-γ-S, GDP-β-S, and AlF3 in ways that confirmed G-protein involvement. The selective effect of nociceptin on IBa,T may therefore be relevant to understanding why its behavioral actions differ from those of other opioids. This G-protein-independent effect of the action of nociceptin may reflect a new general mechanism of action for opioid peptides within the nervous system.

Nociceptin Inhibits T-Type Ca2+Channel Current in Rat Sensory Neurons by a G-Protein-Independent Mechanism

Nociceptin Inhibits T-Type Ca²⁺Channel Current in Rat Sensory Neurons by a G-Protein-Independent Mechanism