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The inactivation kinetics of the Na+ current of the weakly electric fish Sternopygus are modified by treatment with androgens. To determine whether phosphorylation could play a role in this effect, we examined whether activation of protein kinase A by 8 bromo cyclic AMP (8 Br cAMP) altered voltage-dependent properties of the current. Using a two-electrode voltage-clamp procedure, we found no effect of 8 Br cAMP on inactivation kinetics or other voltage-dependent properties of the Na+current of the electrocytes. However, treatment with 8 Br cAMP did produce a dose-dependent increase in the Na+current compared with saline controls: 17.6% at 100 μm, 42.4% at 1 mm, and 43.1% at 5 mm. This effect was blocked by 30 μm H89, a PKA inhibitor, indicating that the observed effect was attributable to 8 Br cAMP activation of PKA. We conclude that androgen-induced changes in Na+current inactivation are not mediated by PKA and suggest that PKA-mediated increases in Na+ current underlie increases in the amplitude of the electric organ discharge observed in social interactions or with changes in water conductance.

Protein Kinase A Activation Increases Sodium Current Magnitude in the Electric Organ ofSternopygus