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Postembedding immunogold electron microscopy was used to determine the relation of primary afferent terminals in superficial laminae of the spinal dorsal horn with AMPA receptor subunits. Immunogold particles coding for GluR1 and GluR2/3 were concentrated at synaptic sites, between 30 nm outside and 40 nm inside the postsynaptic membrane. Immunopositive synapses displayed round vesicles and asymmetric specializations, characteristic of terminals releasing excitatory neurotransmitters; symmetric synapses, characteristic of terminals releasing inhibitory amino acids, were immunonegative. In superficial laminae, large terminals of two main types at the center of a synaptic glomerulus originate from primary afferents: C1 terminals are mainly endings of unmyelinated afferent fibers; C2 terminals are mainly endings of thinly myelinated afferent fibers. Terminals of both types were presynaptic to AMPA subunits, but in different proportions: C1 terminals were related more to GluR1 than to GluR2/3, whereas the reverse was true for C2 terminals. These results suggest that functional properties of peripheral afferents to the spinal cord may be specified by the density and combination of receptor subunits in the postsynaptic membrane, and raise the possibility that calcium-permeable AMPA channels may play a special role in the mediation of sensory input by unmyelinated fibers.

AMPA Receptor Subunits Underlying Terminals of Fine-Caliber Primary Afferent Fibers