English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In the present study we have investigated the anatomical distribution pattern of nAChR alpha 3, alpha 4, beta 2, and beta 4 subunit mRNAs during prenatal and perinatal development of the rat CNS and PNS. Three main developmental patterns have been recognized. (1) In the majority of cases studied (caudal brain, spinal cord, dorsal root ganglia, trigeminal and geniculate ganglia) all four subunit mRNAs are initially (E11–13) detected but, during subsequent prenatal development, the level of some of these subunit mRNAs (alpha 3 and beta 4 in the brain and spinal cord, alpha 4 and beta 4 in the dorsal root ganglia, alpha 4 in the visceral sensory ganglia, and alpha 3, alpha 4, and beta 4 in the somatic sensory ganglia) become undetectable. (2) In the case of the cerebral cortex a pair of subunit mRNAs (alpha 3-beta 2) is initially (E12–13) expressed followed by a repression of the alpha 3 subunit (E15) and the subsequent (E17–19) induction of the alpha 4 subunit. (3) Only some subunit mRNAs are initially (E13–15) expressed in the retina (alpha 3-alpha 4-beta 2-beta 4), parasympathetic or sympathetic motor ganglia (alpha 3-beta 2-beta 4), and vestibulo- cochlear ganglia (alpha 4-beta 2) and their level remains stable throughout prenatal and early postnatal development. Overall, in most central and peripheral structures the appearance of nAChR subunit mRNAs is precocious and temporally related to the timing of neuronal differentiation. In addition, in several structures the expression of certain subunits (alpha 3, alpha 4 or beta 4) is transient, although not beta 2. Finally, the comparison of the different regional distribution patterns suggests that a limited number of structure- specific receptor isoforms are functional during development of CNS and PNS.

Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems