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Voltage-dependent L-type calcium channels were induced in highly purified, cultured, cortical astrocytes by exposure to substances known to increase their intracellular cAMP: 8-bromo-cAMP, forskolin, isoproterenol, and vasoactive intestinal peptide. In untreated control cultures, L-type calcium currents were entirely absent. The induction of this calcium current was specific to cortical astrocytes and a closely related astrocyte type in white matter and did not occur in meningeal cells or oligodendrocytes. The ability of forskolin to induce L-type calcium current in astrocytes depended on previous culture of these cells in a permissive lot of serum for at least 48 hr. In addition, certain lots of sera caused expression of a voltage-dependent T-type calcium channel in untreated control cultures. Several possible mechanisms of calcium channel induction by cAMP are consistent with our data: modification of a silent channel already present in the membrane, indirect effect of cytoskeletal alteration, or insertion of channels from submembrane stores. If the environment in vivo is permissive, regulation of glial ion channels may be under neuronal control.

Calcium current in cortical astrocytes: induction by cAMP and neurotransmitters and permissive effect of serum factors