English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effects of cAMP on Mauthner (M-) cell excitatory and inhibitory responses were studied in vivo. Cyclic AMP was iontophoresed into the M- cell lateral dendrite, after which we monitored the changes in cellular responsiveness to stimulation of 2 classes of identified presynaptic cells: (1) excitatory fibers from the posterior branch of the ipsilateral eighth cranial nerve and (2) inhibitory interneurons activated by the M-cell collateral and commissural networks. We found that postsynaptic injections of cAMP increased the magnitudes of the electrically and chemically mediated EPSPs from the eighth nerve and enhanced M-cell inhibitory responses as well. Furthermore, cAMP augmented paired-pulse facilitation of both types of excitatory potentials. No effects on input conductance, resting membrane potential, or presynaptic spike width were observed. All effects were mimicked by aminophylline, a cAMP-dependent phosphodiesterase inhibitor but not by 5′-AMP, the cAMP breakdown product. These results provide evidence for second-messenger modulation in vivo of electrotonic and chemical synaptic potentials at mixed synapses. In addition, they provide the first evidence for cAMP modification of a glycinergic receptor-channel complex. Preliminary results from some of these experiments have been reported previously (Wolszon and Faber, 1986).

The effects of postsynaptic levels of cyclic AMP on excitatory and inhibitory responses of an identified central neuron