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Sympathetic ganglia of the frog contain two types of principal neurons, B and C cells, which are innervated by two distinct classes of cholinergic preganglionic axons, B and C fibers. This study examined and compared the kinetics of nicotinic ACh-gated channels that produce the fast excitatory postsynaptic currents (EPSCs) in B and C cells. Neurons were identified and voltage-clamped at -50 mV, 22 degrees C. The EPSC decayed as a single exponential for both cell types, but the decay time constants differed considerably; 10.2 +/- 2.3 msec (mean +/- SD) for C cells and 5.5 +/- 1.1 msec for B cells. Analysis of ACh- induced membrane current fluctuations revealed spectra that fit single- Lorentzian functions and gave estimates of the mean channel open time of 9.8 +/- 2.0 msec and 5.2 +/- 0.9 msec for C and B cells, respectively. Thus, the clear difference in EPSC decay rate for these two types of ganglion cells is most likely due to the differences in the mean lifetimes of their synaptic channels.

Different synaptic channel kinetics in sympathetic B and C neurons of the bullfrog