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The morphology and distribution of neuronal cell bodies and synapses that utilize y-aminobutyric acid (GABA) as a transmitter have been studied in Mczcaca dorsal lateral geniculate nucleus (dLGN), ventral lateral geniculate nucleus (vLGN), and reticular nucleus of the thalamus (RNT). These cells are identified by immunocytochemical staining for the antiserum to the enzyme that synthesizes GABA, glutamic acid decarboxylase (GAD) and visualized by the peroxidase-antiperoxidase method for light and electron microscopy. In the dLGN, GAD-positive (GAD+) cell bodies are found in all layers and in the interlaminar zones. The neuropil is more heavily labeled in the laminar than the interlaminar zones, with the magnocellular layers being most densely labeled. In the vLGN no stained cell bodies are seen, but the neuropil is intensely GAD+, especially in the retinal input layer. The RNT is just the opposite, with many GAD+ neurons but sparsely labeled neuropil. The GAD+ neurons in dLGN have small cell bodies with a large infolded, unlabeled nucleus. GAD reactivity is found in the thin rim of cytoplasm and in the two to four thick, straight dendrites, and on the cytoplasmic surfaces of mitochondria, Golgi and membraneous cisternae, and vesicles. GAD+ synaptic profiles are found in both preand postsynaptic relationships in the dLGN. Some GAD+ profiles are both preand postsynaptic in the same section, suggesting that these are presynaptic dendrites. In the laminae, GAD+ presynaptic profiles are very commonly found within synaptic glomeruli where they lie postsynaptic to a retinal axon terminal and presynaptic to an unlabeled dendrite, which also receives input from the retinal terminal. Outside of glomeruli, individual GAD+ profiles are presynaptic to either labeled or unlabeled cell bodies and dendrites. Other GAD+ profiles are postsynaptic to unlabeled F or RSD-type terminals. Individual GAD+ profiles ending on unlabeled or labeled dendrites are found in the interlaminar zones. These data, when combined with previously published work on dLGN circuitry, suggest that GAD+ glomerular profiles are the presynaptic dendrites of the dLGN interneuron, whereas the individual GAD+ contacts arise from axons of RNT neurons. The primate dorsal lateral geniculate nucleus (dLGN) whose processes remain within the dLGN (reviewed by has been the subject of numerous studies that have Guillery, 1971; Wilson and Hendrickson, 1981). In monresulted in a substantial amount of information concernkey, more than 90% of the neurons are labeled after ing its structural organization. It appears to have two horseradish peroxidase injections into striate cortex, inmain neuronal types: projection cells that send their dicating that interneurons are present but scarce (Ogren axons to visual cortex, and intrinsic or interneurons and Hendrickson, 1976; Norden and Kaas, 1978). Several ’ This study was supported by National Institutes of Health Reinvestigators have described a candidate for interneurons search Grants EY-01208, NS18858, EY-03909, NS13224, and in part by in Golgi preparations of monkey dLGN (Polyak, 1957; EY-01730, RRO0166, and HD02274. A. E. H. is the recipient of the Campos-Ortega et al., 1968; Pasik et al., 1973; Saini and Dolly Green Scholar Award from Research to Prevent Blindness, Inc., Carey, 1981; Wilson and Hendrickson, 1981). These cells and a travel grant from the Burroughs WeIIcome Fund. are small with relatively few, straight, long primary den* To whom correspondence should be addressed. drites that branch into elaborate processes with multiple

the journal of neuroscience/the journal of neuroscience

Light and electron microscopic immunocytochemical localization of glutamic acid decarboxylase in monkey geniculate complex: evidence for gabaergic neurons and synapses