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Defects in DNA damage-response and in DNA repair often cause an increase in cancer incidence. Roles of the DNA repair are associated with modulation of hormone signaling pathway. Molecular basis for the progression of prostate cancer which is the most common neoplasm in male population remains an important subject in management of the male cancer. In addition, the molecular mechanisms by which pathogenesis may affect the prostate cancer are poorly elucidated. Epidemiological studies indicate that wide- range of lifestyle might alter the development of the prostate cancer. It has also been shown that exposure to estrogenic hormones changes the expression of epigenetic regulatory genes involved in the DNA repair system. We have attempted to review the function of DNA repair molecules at a viewpoint of prostate carcinogenesis and of lifestyle related DNA damages, providing an understanding on the molecular mechanisms by which estrogen may employ their action on the regulation of prostate cancer.

Roles of Estrogens in Prostate Cancer Development via the Modulation of DNA-Repair System