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The sculpture and handwritten records of the old civilization are treated unwisely through the history. Valuable scientific contents were not well documented or even photocopied. That was lead to the loss of valuable and critical knowledge. However, unwritten knowledge, which were transferred from generation to generation are preserved and still existed and can be recognized in the folks’ daily practices. Some experience persons are in need to catch them. This mini-review is aim to highlight the historical timeline where the Human being has reported diseases and used tools to immunize himself through the history either by chance or by planed processes, including the vaccination. Most of the lost data from different known and unknown resources could be retrieved from the folk practices.

The Folk Memory and Believe: One Candle Eradicate the Small Box; What Else?