English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Grover’s disease is a transient acantholytic dermatosis that usually disappears within a few weeks, but it can also be presented as a persistent variant with a duration of more than 3 years. The etiology of this disease is not entirely clear and possible causes include viral infections, drug reactions (BRAF inhibitors and allogeneic haematopoietic stem cell transplantation). In terms of treatment, topical and systemic steroids, oral vitamin A and PUVA therapy are described. We present a 79-year-old man with a 1-month complaint for a recurring, highly itchy, blistering rash on the skin of the upper limbs, back and chest. During the clinical examination, there was an erythemo-papulo-vesicular polymorphic rash , in places with xerosis areas, engaging the upper part of the trunk, as the initial data and subsequent histopathological verification data spoke undoubtly in direction of acantholytic dermatosis or Grover’s disease .During hospitalization, systemic antihistamine and topical steroid therapy was performed. Subsequently, ambulatory therapy with Acitretin 20 mg /daily per os and Methylprednisolone aceponate 0.1% x 2 / daily topically was given with a good therapeutic response. We believe that this case seems to be the first officially documented case of Morbus Grover associated with idiopathic low-grade thrombocytopenia.  Key words: Morbus Grover; Idiopathic thrombocytopenia; Acitretin; Prednisolone; PSA

clinical research in dermatology

Transient Acantholytic Dermatosis (Grover's Disease) in a Bulgarian Patient Associated With Idiopathic Low-Grade Thrombocytopenia: First Description in the Medical Literature!