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Human skin physiology changes during the course of life involving age-related changes in skin appearance. It has been suggested that eggshell membrane, a natural ingredient containing collagen, hyaluronic acid, elastine, among others, can be used for improving skin. However, there are limited clinical studies using eggshell membrane as a dietary supplement to study skin health. The efficacy of Ovoderm®, an oral supplement from eggshell membrane, on skin biophysical parameters related to cutaneous aging was evaluated. A double-blind, placebo controlled study with 50 healthy subjects randomized to intake 300 mg Ovoderm® or a placebo treatment during 60 days was performed. Skin elasticity, transepidermal waterloss, skin firmness and skin fatigue were measured before and after the treatment. At the end of the study, the group intaking Ovoderm® improved the skins barrier function, showed by the tendency of transepidermal waterloss to decline. With regard to firmness and skin fatigue, a significant improvement was observed in Ovoderm® and placebo treatment, but the enhancement was 33% and 45% higher in Ovoderm® treatment for firmness and fatigue, respectively, than in the placebo treatment. After 60 days of Ovoderm® intake a significant improvement of skin elasticity was proven. These results demonstrate that dietary Ovoderm® can improve the elasticity and the barrier function on human skin. Thus, Ovoderm® is effective to prevent and to reduce the gradual loss of skin elasticity, fatigue and firmness that are characteristic of aged skin. Ovoderm®, safe and well tolerated ingredient, helps to improve the appearance and health of the skin.

Supplementation with Ovoderm® Reduces the Clinical Signs of Skin Aging. A Double-Blind, Placebo-Controlled Study