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Genetic information transferred from DNA to mRNA by transcription is transmitted to protein through translation on ribosome. During the translation, the universal or standard genetic code written with triplet base sequence is used, which specifies a kind of amino acid, like as that GUC, CAC, AAG and UUC correspond to Val, His, Lys and Phe, respectively. As well known, the genetic code is degenerate mainly at the third codon position, for example GGN, GCN and GUN, 4 codons each, code for Gly, Ala and Val, respectively (Figure 1). However, it is totally unknown about the reason why the genetic code is degenerate.

Degeneracy of the Genetic Code has Played an Important Role in Evolution of Organisms