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Background: As quality of life (QOL) is the main focus of palliative care, evaluating QOL is a very important aspect of the care offered to patients. Aim: To produce a Brazilian Portuguese version of the McGill Quality of Life Questionnaire adapted for the Brazilian cultural context and to assess its cross-cultural validity and reliability. Design: The original version was translated into Brazilian Portuguese in accordance with the guidelines in the literature and then adapted to the Brazilian context by conducting interviews until we reached the final version (MQOL-Br). To assess the validity of the MQOL-Br, it was applied together with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire “Core” 30 Items, the Chronic Pain Grade – Brazil and the Karnofsky Performance Scale in interviews with 101 patients from the same population. Clinical validity was tested by conducting a known-groups comparison. Multiple linear regression analysis was used to determine which of the five subscales had independent relationships with overall QOL.The internal consistency was assessed using Cronbach’s α. Testretest reliability was assessed in a second interview with 63 patients 2-8 days after the initial interview. Setting/Participants: Cancer patients in palliative care at the

Cross-cultural Validation of the Brazilian Portuguese Version of the McGill Quality of Life Questionnaire