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Presently, up to 70% of the patients with complaints of reflux symptoms have been noted to have NERD [2]. Despite the potency of proton pump inhibitors (PPIs) on gastric acid secretion, it is now evident that they do not suppress symptoms in patients with GERD as completely as was once supposed. Indeed, with the advent of more thorough symptom evaluation, it is now well recognized that both in the clinical study setting and in ordinary clinical practice, many GERD patients experience persistence of troublesome reflux symptoms while taking PPI therapy [3].

journal of gastroenterology, pancreatology and liver disorders

Efficacy and Safety of Fixed Dose Combination of Pantoprazole and Low Dose Amitriptyline in Indian Population Suffering From GERD with Co- Existing Anxiety