English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The assessment of histological remission started to become a more accurate and favorable therapeutic endpoint in ulcerative colitis (UC). This study aimed to investigate the rate of clinical relapse in UC patients after achieving mucosal healing and to evaluate the predictive role of basal plasmacytosis and microscopic inflammation on disease relapse. Patients and methods: This was a prospective observational study conducted in UC patients with endoscopic remission defined by endoscopic Mayo (eMayo) subscore 0 or 1. All patients underwent a colonoscopy and biopsy samples were taken the colonic mucosa. Follow-up appointments were months 6, and 12. Microscopic inflammation was defined as a Geboes score ≥3.1. Results: Sixty-nine adult UC patients were enrolled in the study. Histology revealed basal plasmacytosis in 81.2% (focal plasmacytosis in 63.8%, diffuse plasmacytosis in 17.4% of the cases) and microscopic inflammatory activity in 37.7% of patients with mucosal healing. At 6 and 12 months, clinical relapse occurred in 16.2%, and in 14.5% of the patients. Geboes score ≥3.1 and plasmacytosis detected in the biopsy samples at baseline were present in 9.1 and 72.7% of the patients’ samples relapsed at month 6, in 40 and 80% of the patients’ samples relapsed at months 12. Neither the presence of basal plasmacytosis, nor Geboes score ≥3.1 was shown to be predictive of disease relapse. Conclusion: The role of histological inflammation with mucosal healing requires more extensive research. Our results suggest that maintaining therapy after achieving endoscopic remission may influence the association between basal plasmacytosis and clinical relapse.

Histological activity and basal plasmacytosis are nonpredictive markers for subsequent relapse in ulcerative colitis patients with mucosal healing