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Irsogladine maleate is a gastro-protective drug that is known to increase mucosal blood flow and facilitate gap junctional intracellular communication, leading to fortification of the tight junctions of the entire gastro-intestinal mucosa. Animal experiments have revealed effects in improving radiation-induced intestinal injuries. Clinical efficacy in stomatitis or enteropathy has also been reported. A 76-year-old male with Behcet’s disease had been diagnosed with prostate cancer when he was 72 years old, and was treated with a combination of hormone and radiation therapy (50.4 Gy in 28 fractions to the small pelvic region plus a 14.4-Gy boost in 8 fractions to the prostate and seminal vesicles). Beginning 3 months after completion of the radiation treatment, rectal bleeding began and he was diagnosed with radiation proctitis. The bleeding gradually became severe, and 2 year’s post-radiation therapy, his hemoglobin level could be maintained at only ~8 g/dL even with vigorous iron supplementation. Endoscopic findings also worsened, to more diffuse friability and telangiectasia, classified as Sherman’s grade Ib. Once irsogladine was administered, the bleeding promptly began to decrease, and his hemoglobin could be maintained above 10 g/dL 4 months later. Iron supplementation was discontinued after 1 year. Endoscopic vascular findings and friability improved correspondingly. Thus, we report a case of Behcet’s disease with radiation proctitis improved markedly by oral administration of irsogladine maleate.

A Case of Behcet’s Disease with Radiation Proctitis Improved by Oral Administration of Irsogladine