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dendrimers, carbon nanotubes, iron oxide nanoparticles, gold nanorods and gold nanoparticles [5-11].Of these, gold nanoparticles (AuNPs) hold immense promise as a carrier due to its large surface to volume ratio, inertness, easy functionalization, low toxicity and ample cell penetration properties [12, 13]. Conjugations of Dox to AuNPs through covalent linkages and surface adsorption have been attempted [14]. In these methods, AuNPs prepared using chemicals such as sodium borohydride or citrate have been utilized which has resulted in non-compatibility towards normal cells. For overcoming this problem, AuNPs synthesized using plant extracts and pure phytochemicals are suggested as alternatives. In addition, delivery of Dox using these AuNPs to cancer cells is also being investigated in recent times. For example, AuNPs prepared using Helminthosporum solani have been used for Dox delivery to cervical cancer cells (HeLa) [15].Azadirachta indica extract capped AuNPs have also been reported to deliver Dox to embryonic kidney cells (HEK239) [16]. Since k-AuNPs have been shown to elicit toxicity to MCF7 cells and preliminary results obtained in our laboratory have indicated that resveratrol (a stillbenoid) conjugated to AuNPs (r-AuNPs)is also able to bring about apoptosis of MCF-7 cells, it is possible that loading of Dox to k-AuNPs and r-AuNPs may enhance the cytotoxicity [17]. Hence, Dox conjugated k-AuNPs and r-AuNPs have been synthesized and characterized and their actions on MCF-7 cells have been investigated.

Biocompatibility, uptake and anti-cancer activity of doxorubicin loaded gold nanoparticles in MCF-7 breast cancer cell line