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Objectives: The current study aimed to evaluate 1) the impact of the regular running practice 2) as well the acute effect of running race on inflammatory markers and DNA methylation status in peripheral blood of health elderly men. Methods: Fifteen male volunteers aged 60 years and older were recruited. They were allocated in two groups: runners (RUN, n=8) and sedentary (SED, n=7), considering if they were sedentary or amateur street runners. All participants, SED and RUN groups, were submitted to a basal blood collection. After 5 days, two blood samples were collected in the RUN group: 30 min before and immediately after a 5-10km outdoor running performance.The blood samples (15mL) were collected for the epigenetic and inflammatory measurements, which were done using specific kits, according to the manufacturer’s instructions. Results: FIn the basal period, no significant differences were observed on DNA global methylation status between the SED and RUN groups. However, the SED group showed increased IL-4 and IL-6 levels when compared to the RUN individuals (p= 0,040 and 0,035, respectively). The IL-6 and IL-4 levels were significantly higher in the EXE group after the running performance compared to the before running period (p=0,004 and 0,013 respectively), while DNA methylation status remained unaltered. Conclusion: Our data suggest that DNA methylation status might not be consider a potential biomarker related to the healthy elderly runners phenotype. Furthermore, the inflammatory response may indicate a possible regulatory effect provided by the endurance exercise in the elderly group because IL-4 and IL-6 are synergic cytokines directing an immune response.

The Running Practice Modulates Inflammatory Markers and not Alters Global DNA Methylation in Elderly Men