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Background: Thyroid hormones are the most commonly prescribed tests in the clinical set up. Variations are observed in individuals of different age, sex, race and nutritional status. However few studies describe these changes in children. The aim of the present study was to evaluate thyroid hormones in children of East Delhi with respect to gender, age and season. Methods: The study included 850 children up to 12 years of age of both genders who attended the hospital for thyroid hormone analysis. Subjects suffering from thyroid disorders or those on medication affecting hormone status were excluded from the study. Non-fasting venous samples were collected and serum FT3, FT4 and TSH levels were estimated by chemiluminesence method. Statistical analysis was done by using unpaired t-test and ANOVA. Results: TSH levels were found to be statistically higher in the female subjects (p = 0.049). On evaluating hormones age wise FT3 levels were found to increase significantly with age (p = 0.000) whereas FT4 and TSH levels significantly declined with age (p = 0.000 and p = 0.039). Significant seasonal variation in hormones was also observed. Conclusions: Our results shows that thyroid hormone levels change markedly in childhood. Variation in thyroid hormone levels has to be kept in mind during evaluation and treatment of thyroid disorders in children.

Effect of Age, Gender and Season on Thyroid Hormones Status in Children of East Delhi- A Hospital Based Study