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Since Framingham we are assuming that age, smoking, hypertension, diabetes, obesity and family history are the main risk factors for cardiovascular disease, stroke and atherosclerosis. In spite of aggressive strategies, medication for cholesterol, diabetes and hypertension, and low fat diet approach, the incidence of cardiovascular disease is on the rise in western countries. Moreover, life expectancy in the USA is for the first time falling down in the last decades. Alternative approaches has claim the importance of heavy metals chronic exposure, lack of Vitamin C and Vitamin K, periodontal disease and stress as fundamental risk factors and coadjutants for atherosclerosis. Some of these so called atypical factors are described in this article.

Non Typical Risk Factors in Atherosclerosis and Coronary Disease. It Is Time to Open the Box and Look Outside