English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The aim of the current research work was to formulate drug loaded nano-suspension using novel bioexcepient isolated from kernels of Prunus amygdalus and to explore the capability of external acoustic meatus as novel acoustic drug delivery system. The biomaterial was extracted by simplified economical process and was further purified by hot dialysis method. The isolated biomaterial was subjected to various physicochemical evaluations along with spectral analysis including UV, IR, Mass, NMR, SEM. The bio-nano suspension formulated with the novel bioexcepient was tested for its functional properties, like retardability, stability and mucoadhesitivity using shear stress method. Different formulations of duloxetine were prepared by using biomaterial as a retardant cum stabilizer and glycerin as nanosizent. The formulations were subjected to various evaluations, including pH, dispersibility, Entrapment efficiency, Particle size, mucoadhesion, skin irritancy, in-vitro release, for over 36 hours Stability. Experimental result reveal that the biopolymer posses promising retardibility cum stability and mucoadhesivity. According to the in-vitro and pharmacodynamic results obtained it can be concluded that significant amount of drug reaches to the brain via external acoustic meatus and so it is feasible to deliver Duloxetine by acoustic meatus.

Formulation and evaluation of Duloxetine loaded bio-nano suspension for brain specificity via acoustic meatus