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The frequency of meningioma is nearly twice as high in females as in males [1]. This difference in incidence is partly explained by molecular and immunehistochemical studies’ indicating that meningioma is sensitive to hormones. Approximately 70% of meningiomas express progesterone receptors and 30% express estrogen receptors [2-4]. It has also been observed that meningioma cells tend to proliferate when exposed to estrogen and progesterone [4].

Meningioma: The Unusual Growth in a Transsexual Patient after Estrogen-Progesterone Therapy