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Patients with certain types of primary immunodeficiencies display a number of musculoskeletal changes. In patients with primary immunodeficiencies, septic arthritis due to pyogenic bacteria or mycoplasmal arthritis is the most common osteoarticular manifestation. In certain PIDs, chronic, noninfectious arthritis resembling rheumatoid arthritis may occur. In this paper we have extensively reviewed musculoskeletal and osteoarticular changes in PIDs and presented them under most recent IUIS primary immunodeficiency classification.

Skeletal and Joint Manifestations of Primary Immunodeficiency Diseases