English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We report here a case of methotrexate-associated lymphoproliferative disorder (MTX-LPD) diagnosed on detection of gingival ulceration. A 54-year-old woman presented to our clinic with a chief symptom of multiple maxilla-mandibular gingival ulcers. Histopathological diagnosis was MTX-LPD of the Hodgkin-like lesion type along with EBV positivity. The condition was treated by MTX withdrawal during the 3 months of remission. We reviewed reports documenting 24 cases of oral MTX-LPD in Japan. Affected sites included the maxillary gingiva (n= 13), the mandibular gingiva (n=4), the maxillary-mandibular gingiva (n=1), tongue (n=3), floor of the mouth (n=2), and lips (n=1). Of these 24 cases, 20 ulcers were severe, with 3 involving bony exposure and a fistula. Histopathological analysis revealed 15 DLBCL cases, a Hodgkin-like lesion case, 2 polymorphous B-cell LPD, a B-cell LPD, a T-cell dominant LPD, a polymorphic LPD, and 3 cases of unknown etiology. Nineteen cases were treated with MTX withdrawal, and 5 cases were treated with MTX withdrawal and chemotherapy. With treatment, 21 patients attained remission, 1 patient died of the primary disease, and 1 other died owing to secondary complications. Twenty cases attained remission with the withdrawal of MTX without recurrence.

A Case of Methotrexate-associated Lymphoproliferative Disorder Diagnosed on Detection of Ulceration of the Gingiva