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Coronary artery disease (CAD) is one of the major causes of disability and death in the world. Accordingly utilizing from a national and update guideline in heart-related disease are essential. Finding interesting rules from CAD data and comparison with guidelines was the objectives of this study.  Methods:  In this study 1993 valid and completed records related to patients (from 2009 to 2014) who had suffered from CAD were recruited and analyzed. Total of 25 variable including a target variable (CAD) and 24 inputs or predictor variables were used for knowledge discovery. To perform comparison between extracted knowledge and well trusted guidelines, Canadian Cardiovascular Society (CCS) guideline and US National Institute of Health (NIH) guideline were selected. Results of valid datamining rules were compared with guidelines and then were ranked based on their importance.  Results:  The most significant factor influencing CAD was chest pain. Elderly males (age &gt;54) have a high probability to be diagnosed with CAD. Diagnostic methods that are listed in guidelines were confirmed and ranked based on analyzing of local CAD patients data. Knowledge discovery revealed that blood test has more diagnostic value among other medical tests that were recommended in guidelines.  Conclusion:  Guidelines confirm the achieved results from data mining (DM) techniques and help to rank important risk factors based on national and local information. Evaluation of extracted rules determined new patterns for CAD patients.

Comparison of coronary artery disease guidelines with extracted knowledge from data mining