English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Ulcerative colitis is a chronic inflammatory disease which reduces the quality of life and patients’productivity. People in different ages could be affected since its complications such as colon perforation andcancer are common. Oxidative stress is reported to create an imbalance between reactive oxygen species (ROS)and antioxidant defense systems which occurs in inflammatory tissues and predisposing malignant tumors.Objectives: We aimed to evaluate the effects of omega-3 on inflammatory, antioxidant, and oxidative markers ofpatients with ulcerative colitis.Patients and Methods: Seventy elderly patients with ulcerative colitis referring to Rasoul-e-Akram hospital (IranUniversity of Medical Sciences) with mild or moderate phase of the disease were investigated. Patients wereundergoing their protocol treatment. Patients were randomly assigned to the block randomization assignment,including 35 patients (routine + omega-3) or control (routine + placebo). Based on a researcher-made checklist,the severity of the disease, as well as the oxidant, antioxidant, and inflammatory factors of the patients weredetermined before and after 2 months of treatment. Finally, the changes in these factors were compared betweengroups.Results: Among the 70 participants, 35 were in the control and 35 in the intervention group. All subjects werepresent during the whole period of the study, so the attrition rate was 0%. No significant difference was observedbetween the mean of BMI (body mass index) as kg/m2, waist circumference (cm), systolic pressure (mm Hg), anddiastolic pressure (mm Hg) in both groups before and after the intervention. The measure of optimal changesin serum levels of MDA (malondialdehyde oxidant), AGEs (advanced glycation end-products), oxidized LDL(oxidized low density lipoprotein), TNF-α (tumor necrosis factor-alpha) and the improvement of antioxidantcatalase copper markers were significantly higher in the intervention group, compared to the control one.Conclusion: Administration of omega-3 as an auxiliary component in the treatment of patients significantlyreduced the levels of inflammatory and oxidative markers and a significant increase in antioxidant markers in theserum and improved blood pressure in patients with ulcerative colitis.

Comparing the effect of including omega-3 to treatment regimen in elderly patients with ulcerative colitis with placebo: A randomized clinical tria